Preferred Label : MVA-FCU1 TG4023;
NCIt synonyms : Modified Ankara Virus-Mediated Suicide Gene Delivery Vector TG4023;
NCIt definition : A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector
encoding the suicide gene FCU1 with potential antineoplastic activity. FCU1 is a bifunctional
yeast cytosine deaminase (CD) / uracil phosphoribosyltransferase (UPRT) fusion gene.
Upon intratumoral administration, MVA-FCU1TG4023 enters tumor cells where FCU1 is
expressed. Subsequently, the noncytotoxic prodrug 5-fluorocytosine (5-FC) is administered
systemically and is deaminated by CD in FCU1- transduced tumor cells into 5-fluorouracil
(5-FU), which is then directly metabolized to 5-fluoro-uridine monophosphate (5-FUMP)
by UPRT; 5-FUMP may then be further transformed to 5-fluoro-deoxyuridine monophosphate
(5-FdUMP), an irreversible inhibitor of thymidylate synthase and, so, DNA synthesis
through deprivation of deoxythymidine triphosphate (dTTP). 5-FU and its active metabolites
may then selectively kill tumor cells, avoiding toxicity in nonmalignant cells. The
MVA viral vector, derived from the replication-competent strain Ankara, is a highly
attenuated, replication-defective vaccinia strain incapable of virion assembly.;
Molecule name : TG4023;
NCI Metathesaurus CUI : CL412469;
Origin ID : C88279;
UMLS CUI : C2981801;
Semantic type(s)
- concept_is_in_subset
