Preferred Label : Technetium Tc-99m Demobesin-4;
NCIt synonyms : 99mTc Demobesin-4;
NCIt related terms : technetium Tc 99m demobesin-4;
NCIt definition : A radioconjugate composed of the synthetic bombesin (BB) analog demobesin-4 bound
to the radioisotope technetium Tc 99m with receptor ligand and gamma-emitting radioisotope
activities. Upon intravenous administration, demobesin-4 selectively binds to the
gastrin-releasing peptide receptor (GRPR) expressed on the surfaces of various tumor
cell types; upon internalization, tumor cells expressing GRPRs bound to technetium
Tc 99m can then be visualized using scintigraphy. GRPR, a bombesin receptor subtype,
is frequently overexpressed on the surface of tumor cells such as prostate and breast
cancer cells. Demobesin-4 was developed for technetium Tc 99m imaging of GRPR-expressing
tumor cells.;
Alternative definition : NCI-GLOSS: A substance being studied as a way to find certain types of cancer. It
contains a radioactive substance called technetium linked to another substance called
demobesin. Demobesin binds to the receptor for bombesin (a substance that is found
at higher-than-normal levels on some types of cancer cells). Technetium Tc 99m demobsin-4
collects in cancer cells and a machine is used to find where the cancer cells are
in the body. It is a type of radiopharmaceutical and a type of radioimaging agent.;
NCI Metathesaurus CUI : CL412465;
Codes from synonyms : CDR0000661207;
Origin ID : C88276;
UMLS CUI : C2981798;
Semantic type(s)
- concept_is_in_subset
