NCIt definition : An orally bioavailable quinoline-urea derivative inhibitor of vascular endothelial
growth factor receptors (VEGFRs) 1 and 2 with potential antiangiogenesis and antineoplastic
activities. VEGFR inhibitor KRN951 inhibits VEGF-induced phosphorylation of VEGFRs
1 and 2, which may result in inhibition of migration, proliferation and survival of
endothelial cells, microvessel formation, the inhibition of tumor cell proliferation,
and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor
cell types.;
Currated CISMeF NLP mapping