Preferred Label : C-VISA BikDD:Liposome;
NCIt synonyms : C-VISA BikDD Plasmid: DOTAP:Cholesterol Liposome-Based Nanoparticle;
NCIt definition : A formulation composed of DOTAP:cholesterol liposome nanoparticles complexed with
the plasmid C-VISA BiKDD, with potential antineoplastic activity. C-VISA BikDD: liposome
consists of a pancreatic-cancer-specific expression vector VISA (VP16-GAL4-WPRE integrated
systemic amplifier) and a pancreatic-cancer-specific promoter CCKAR (cholecystokinin
type A receptor) (CCKAR-VISA or C-VISA) which drives expression of the gene BikDD,
a mutant form of the potent proapoptotic gene Bik (Bcl-2 interacting killer). Upon
administration and transduction into pancreatic tumor cells, expression of BikDD by
C-VISA BikDD:liposome may induce pancreatic tumor cell apoptosis and suppress pancreatic
tumor cell proliferation. BikDD binds with greater affinity to anti-apoptotic proteins
bcl-2, bcl-xl, bcl-w and Mcl-1 and is more potent than wild-type Bik. DOTAP:cholesterol
liposome is composed of cationic lipid dioleoyl-trimethylammonium propane (DOTAP)
and cholesterol at molar ratio of 1:1.;
NCI Metathesaurus CUI : CL412442;
Origin ID : C88264;
UMLS CUI : C2981787;
Semantic type(s)
- concept_is_in_subset
