Preferred Label : Ad5.SSTR/TK.RGD;
NCIt synonyms : RGD-Modified Adenoviral Vector Encoding SSTR/TK;
NCIt definition : An RGD-4C-modified, infectivity-enhanced, bicistronic type 5 adenovirus expressing
herpes simplex virus thymidine kinase (HSV-tk) gene, a therapeutic suicide gene, and
the somatostatin receptor type 2 (SSTR2) gene with potential antineoplastic activity.
Modification with the double cyclic peptide RGD-4C allows the virus to bind to cellular
integrins, frequently expressed on the surfaces of ovarian cancer cells, instead of
the coxsackie and adenovirus (CAR) receptor, which is often nonfunctional in ovarian
cancer cells. Upon intratumoral administration, Ad5.SSTR/TK.RGD transfects tumor cells
and expresses the HSV-tk gene. After subsequent administration of a synthetic acyclic
guanosine analogue prodrug like ganciclovir (GCV), expressed HSV-tk phosphorylates
and activates the prodrug, which may result in inhibition of DNA synthesis and apoptosis
in HSV-tk-expressing cancer cells. Additionally, as a bystander effect, adjacent non-transfected
cells may be killed by the activated antiviral drug. SSTR2 expression allows imaging
of gene transfer into tumor cells using a radiolabeled somatostatin analogue.;
NCI Metathesaurus CUI : CL412438;
Origin ID : C88261;
UMLS CUI : C2981785;
Semantic type(s)
- concept_is_in_subset
