LAPTM4B wt Allele

Preferred Label : LAPTM4B wt Allele;

NCIt synonyms : LC27; LAPTM4beta; Lysosomal Protein Transmembrane 4 Beta wt Allele;

NCIt definition : Human LAPTM4B wild-type allele is located in the vicinity of 8q22.1 and is approximately 146 kb in length. This allele, which encodes lysosomal-associated transmembrane protein 4B, may be involved in transport. Amplification of the gene may be associated with hepatocellular carcinoma and both anthracycline resistance and metastatic recurrence in breast cancer.;

NCIt note : Expression is analyzed as part of the 17-gene leukemia stem cell scoring system (LSC17). (Nature. 2016; doi:10.1038/nature20598.);

GenBank Accession Number : AF317417;

Details

Origin ID

C88216;

UMLS CUI

C2981743;

OMIM relation
- Lysosome-associated protein, transmembrane 4, beta [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_associated_with_disease
- Recurrent Breast Carcinoma [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 8q22.1 [NCIt concept]
gene_plays_role_in_process
- Drug Resistance Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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