NCIt synonyms : Stage IVB Mycosis Fungoides and Sézary Syndrome AJCC v7; Stage IVB Mycosis Fungoides and Sézary Syndrome;
NCIt related terms : Stage IVB Mycosis Fungoides and Sezary Syndrome;
NCIt definition : Stage IVB includes: T1-4, N0-3, M1, B0-2. T1: Limited patches, papules, and/or plaques
covering less than 10% of the skin surface. May further stratify into T1a (patch only)
vs. T1b (plaque /- patch). T2: Patches, papules, or plaques covering 10% or more
of the skin surface. May further stratify into T2a (patch only) vs. T2b (plaque /-
patch). T3: One or more tumors (equal or greater than 1 cm diameter). T4: Confluence
of erythema covering 80% or more of body surface area. N0: No clinically abnormal
peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph
nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral
lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral
lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative.
M1: Visceral involvement (must have pathology confirmation and organ involved should
be specified). B0: Absence of significant blood involvement: 5% or less of peripheral
blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than
5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the
criteria of B2. B2: High blood tumor burden: 1000/microL Sezary cells or more with
positive clone. (AJCC 7th ed.);