Preferred Label : Stage IV Mycosis Fungoides and Sezary Syndrome AJCC v7;
NCIt synonyms : Stage IV Mycosis Fungoides and Sézary Syndrome AJCC v7; Stage IV Mycosis Fungoides and Sézary Syndrome;
NCIt related terms : Stage IV Mycosis Fungoides and Sezary Syndrome; stage IV mycosis fungoides and the Sezary syndrome;
NCIt definition : Stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4,
N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10%
of the skin surface. May further stratify into T1a (patch only) vs. T1b (plaque /-
patch). T2: Patches, papules, or plaques covering 10% or more of the skin surface.
May further stratify into T2a (patch only) vs. T2b (plaque /- patch). T3: One or
more tumors (equal or greater than 1 cm diameter). T4: Confluence of erythema covering
80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes;
biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology
Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology
Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology
Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement.
M1: Visceral involvement (must have pathology confirmation and organ involved should
be specified). B0: Absence of significant blood involvement: 5% or less of peripheral
blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than
5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the
criteria of B2. B2: High blood tumor burden: 1000/microL Sezary cells or more with
positive clone. (AJCC 7th ed.);
Alternative definition : NCI-GLOSS: Stage IV is divided into stages IVA and IVB. In stage IVA, most of the
skin is reddened, and any amount of the skin is covered with patches and/or plaques
(areas of abnormal tissue) or tumors (lumps of malignant cells). Cancer has spread
to lymph nodes, and the lymph nodes may be enlarged. In stage IVB, most of the skin
is reddened, and any amount of the skin is covered with lesions or tumors. Cancer
has spread to other organs in the body. Lymph nodes may be enlarged and cancer may
have spread to them. Stage IV may also be classified based on how many abnormal lymphocytes
(white blood cells) are found in the blood.;
Neoplastic status : Malignant;
Codes from synonyms : CDR0000454841;
Origin ID : C88160;
UMLS CUI : C0862226;
Currated CISMeF NLP mapping
- Disease excludes abnormal cell
- Disease excludes normal cell origin
- Has associated anatomic sites
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_is_stage
- disease_may_have_molecular_abnormality
