NCIt definition : A synthetic, aralkylguanidine analogue of the adrenergic neurotransmitter norepinephrine
(NE) and adrenergic neuron blocking agent with potential diagnostic imaging or antineoplastic
activity when radiolabeled. Iobenguane, also known as metaiodobenzylguanidine (MIBG),
is taken up and accumulates in the granules of adrenal medullary chromaffin cells
and in the pre-synaptic granules of adrenergic neurons in a manner almost identical
with that of NE. In radiolabeled forms, iobenguane may be used to image or eradicate
neuroendocrine tissues and tumor cells.;