Monophosphoryl Lipid A

Preferred Label : Monophosphoryl Lipid A;

NCIt synonyms : 3-O-Desacyl-4'-Monophosphoryl Lipid A; 3-Deacylated Monophosphoryl Lipid A; MPL; MPLA;

NCIt definition : A modified form of lipid A, the biologically active part of Gram-negative bacterial lipopolysaccharide (LPS) endotoxin, and a Toll-like receptor 4 (TLR4) agonist, with potential immunostimulatory activity. As a vaccine adjuvant, monophosphoryl lipid A (MPLA) stimulates both cellular and humoral responses to the vaccine antigen. Compared to LPS, MPLA exerts a similar immunostimulatory activity but with reduced toxicity.;

UNII : MWC0ET1L2P;

CAS number : 88598-53-2;

Chemical formula : C96H181N2O21P;

Details

Origin ID

C87754;

UMLS CUI

C0066776;

Automatic exact mappings (from CISMeF team)
- MPL proto-oncogene, thrombopoietin receptor [ORDO Gene]
- Mpl protooncogene, thrombopoietin receptor [OMIM gene]
- maximum permissible level [IUPAC Term]
- medial pes lemniscus [UBERON concept]
Currated CISMeF NLP mapping
- monophosphoryl lipid A [MeSH concept]
- monophosphoryl lipid A [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- monophosphoryl lipid A [MeSH concept]
- monophosphoryl lipid A [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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