Preferred Label : Picropodophyllin;
NCIt synonyms : Picropodophyllotoxin; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,(5R-(5-alpha,5a-alpha,8a-alpha,9-alpha))-;
NCIt definition : A cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum),
and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R)
with potential antineoplastic activity. Picropodophyllin specifically inhibits the
activity and downregulates the cellular expression of IGF1R without interfering with
activities of other growth factor receptors, such as receptors for insulin, epidermal
growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem
cell growth factor (KIT). This agent shows potent activity in the suppression o f
tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor
tyrosine kinase overexpressed in a variety of human cancers, plays a critical role
in the growth and survival of many types of cancer cells.;
UNII : 0F35AOI227;
InChIKey : YJGVMLPVUAXIQN-HAEOHBJNSA-N;
CAS number : 477-47-4;
Molecule name : AXL1717;
Chemical formula : C22H22O8;
NSC code : 36407;
Origin ID : C87736;
UMLS CUI : C0961664;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
