" /> Macitentan - CISMeF





Preferred Label : Macitentan;

NCIt synonyms : N-(5-(4-Bromophenyl)-6-(2-((5-Bromopyrimidin-2-Yl)Oxi)Ethoxy)Pyrimidin-4-Yl)-N'-Propylsulfuric Diamide; Actelion-1;

NCIt definition : An orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.;

UNII : Z9K9Y9WMVL;

InChIKey : JGCMEBMXRHSZKX-UHFFFAOYSA-N;

CAS number : 441798-33-0;

Molecule name : ACT-064992;

Chemical formula : C19H20Br2N6O4S;

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11/05/2025


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