Bedaquiline - CISMeF

Preferred Label : Bedaquiline;

NCIt synonyms : 3-Quinolineethanol, 6-Bromo-Alpha-(2-(Dimethylamino)Ethyl)-2-Methoxy-Alpha-1-Naphthalenyl-Beta-Phenyl-, (Alpha-S,Beta-R)-; 1-(6-bromo-2-methoxy-quinolin-3-yl)-4-dimethylamino-2-(3-fluorophenyl)-1-phenyl-butan-2-ol;

NCIt definition : An orally bioavailable diarylquinoline antimycobacterial agent, that can be used in the treatment of pulmonary multi-drug resistant tuberculosis (MDR-TB). Upon oral administration, bedaquiline specifically binds to subunit c of Mycobacterium tuberculosis (M. tuberculosis) adenosine 5'-triphosphate (ATP) synthase, thereby preventing ATP synthase activity. This inhibits ATP synthesis in M. tuberculosis, thereby blocking its energy metabolism and killing M. tuberculosis.;

UNII : 78846I289Y;

InChIKey : QUIJNHUBAXPXFS-XLJNKUFUSA-N;

CAS number : 843663-66-1;

Molecule name : R207910; TMC207;

Chemical formula : C32H31BrN2O2;

Details

Origin ID

C87658;

UMLS CUI

C1664205;

Automatic exact mappings (from CISMeF team)
- Product containing bedaquiline (medicinal product) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Bedaquiline [LOINC component]
- Bedaquiline [ICD-11 Extension code]
- Bedaquiline [SMS substance]
- Bedaquiline (substance) [SNOMED CT concept]
- bedaquiline [MeSH Supplementary Concept]
- bedaquiline [MeSH concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Bedaquiline [LOINC component]
- Bedaquiline (substance) [SNOMED CT concept]
- Product containing bedaquiline (medicinal product) [SNOMED CT concept]
- bedaquiline [MeSH Supplementary Concept]
- bedaquiline [ATC Code]
- bedaquiline [MeSH concept]
Validated automatic mappings to BTNT
- bedaquiline [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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