Preferred Label : Artenimol;
NCIt synonyms : Dihydroartemisinin; (3R,5AS,6R,8AS,9R,10S,12R,12AR)-Decahydro-3,6,9-Trimethyl-3,12-Epoxy-12H-Pyrano(4,3-J)-1,2-Benzodioxepin-10-ol;
NCIt definition : An active metabolite of artesunate, with anti-malarial activity, and potential insulin
sensitivity-improving, anti-inflammatory, immunomodulating and antineoplastic activities.
Upon administration of artenimol and the hydrolysis of its active endoperoxide bridge
moiety by liberated heme in parasite-infected red blood cells (RBCs), reactive oxygen
species (ROS) and carbon-centered radicals form, which damage and kill parasitic organisms.
Artenimol may also increase insulin sensitivity and improve insulin resistance. In
addition, artenimol induces the 26S proteasome-mediated degradation of the androgen
receptor (AR), thereby lowering AR expression, which may prevent androgen-responsive
cellular proliferation. It also reduces luteinizing hormone LH) and testosterone levels,
and may improve polycystic ovary syndrome (PCOS). In addition, artenimol may modulate
the immune system and may inhibit tumor cell proliferation through various apoptotic
and non-apoptotic pathways.;
UNII : 6A9O50735X;
InChIKey : BJDCWCLMFKKGEE-ISOSDAIHSA-N;
CAS number : 81496-81-3;
Chemical formula : C15H24O5;
Origin ID : C87432;
UMLS CUI : C2828299;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- 3,12-epoxy-12h-pyrano[4,3-j]-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-,
(3r,5as,6r,8as,9r,10s,12r,12ar)- [Substance BNPC]
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
