" /> Laropiprant - CISMeF





Preferred Label : Laropiprant;

NCIt synonyms : (-)-((3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta(b)indol-3-yl)acetic Acid;

NCIt definition : A prostaglandin D2 receptor (DP1) antagonist with niacin-induced vasodilation inhibiting activity. Laropiprant binds to and inhibits the activity of DP1, a G-protein coupled receptor. Via competing with prostaglandin D2 (PG D2) for binding to DP1, this agent prevents PG D2-induced vasodilation and increased blood flow. As niacin induces the synthesis of PG D2, predominantly in the skin, administration of laropiprant may prevent niacin-induced vasodilation in the skin and facial flushing.;

UNII : G7N11T8O78;

InChIKey : NXFFJDQHYLNEJK-CYBMUJFWSA-N;

CAS number : 571170-77-9;

Molecule name : MK-0524;

Chemical formula : C21H19ClFNO4S;

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18/06/2025


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