NCIt definition : An inorganic form of the trace element selenium with potential antineoplastic activity.
Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide
(H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide
radicals upon reaction with oxygen. This may inhibit the expression and activity of
the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression
and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer
cells and inhibit tumor cell proliferation.;
Semantic type(s)