Preferred Label : Berberine Chloride;
NCIt synonyms : Berberine Chloride Dihydrate; Berberinum Chloride; 5,6-Dihydro-9,10-Dimethoxybenzo(G)-1,3-Benzodioxolo(5,6-A)Quinolizinium Chloride; Berberine Hydrochloride;
NCIt definition : The orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium
salt of an isoquinoline alkaloid and active component of various Chinese herbs, with
potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and
antidiabetic activities. Although the mechanisms of action through which berberine
exerts its effects are not yet fully elucidated, upon administration this agent appears
to suppress the activation of various proteins and/or modulate the expression of a
variety of genes involved in tumorigenesis and inflammation, including, but not limited
to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1),
B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2,
tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase
(iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant
protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1),
hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription
3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase
(NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce
cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition,
berberine modulates lipid and glucose metabolism.;
UNII : UOT4O1BYV8;
InChIKey : VKJGBAJNNALVAV-UHFFFAOYSA-M;
CAS number : 633-65-8;
Chemical formula : C20H18NO4.Cl;
Origin ID : C87331;
UMLS CUI : C0873019;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
