Preferred Label : Tolfenamic Acid;
NCIt synonyms : N-(3-Chloro-O-Tolyl)Anthranilic; 2-((3-Chloro-2-Methylphenyl)Amino)Benzoic Acid;
NCIt definition : An orally available, benzoic acid derivative and a non-steroidal anti-inflammatory
drug (NSAID) with anti-inflammatory, antipyretic, analgesic and potential anti-neoplastic
activities. Tolfenamic acid inhibits the activity of the enzymes cyclooxygenase (COX)
I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes.
The decrease in prostaglandin synthesis results in the therapeutic effects of this
agent. Tolfenamic acid also inhibits thromboxane A2 synthesis, by thromboxane synthase,
which decreases platelet aggregation. In addition, this agent exerts anti-tumor effects
through COX-dependent and independent pathways. Specifically, this agent induces the
production of reactive oxygen species, causes DNA damage, increases nuclear factor-kappa
B (NF-kB) activation and the expression of activating transcription factor 3 (ATF3)
and NSAID-activated gene-1 (NAG1), and inhibits the expression of specificity proteins
(Sp), which reduces the expression of Sp-dependent anti-apoptotic and growth-promoting
proteins. Altogether, this enhances tumor cell apoptosis, and reduces tumor cell growth
and angiogenesis.;
UNII : 3G943U18KM;
InChIKey : YEZNLOUZAIOMLT-UHFFFAOYSA-N;
CAS number : 13710-19-5;
Chemical formula : C14H12ClNO2;
Origin ID : C87328;
UMLS CUI : C0076799;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
