Preferred Label : Dienogest;
NCIt synonyms : 19-Norpregna-4,9-Diene-21-Nitrile, 17-Hydroxy-3-Oxo-, (17Alpha)-; 17-Hydroxy-3-Oxo-19-Nor-17Alpha-Pregna-4,9-Diene-21-Nitrile;
NCIt definition : An orally-active, semisynthetic, fourth generation, nonethinylated progestogen with
antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities
that is used in hormone therapy and as a female contraceptive. Upon oral administration,
dienogest binds intracellular progesterone receptors which then translocate to the
nucleus where the drug-receptor complex interacts with progesterone response elements,
thus altering the expression of target genes. Dienogest reduces the production of
estradiol, prevents ovulation and alters the cervical mucus and endometrium. In addition,
dienogest appears to suppress the expression of cell cycle regulator cyclin D1. Altogether,
this may prevent the growth of endometrial epithelial cells and may reduce symptoms
associated with leiomyoma.;
UNII : 46M3EV8HHE;
InChIKey : AZFLJNIPTRTECV-FUMNGEBKSA-N;
CAS number : 65928-58-7;
Molecule name : ZK 37659; MJR-35; STS 557; M 18575;
Chemical formula : C20H25NO2;
Origin ID : C87238;
UMLS CUI : C0057916;
Automatic exact mappings (from CISMeF team)
- CISMeF manual mappings
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
