Preferred Label : Peretinoin;
NCIt synonyms : (2E,4E,6E,10E)-3,7,11,15-Tetramethylhexadeca-2,4,6,10,14-Pentaenoic Acid;
NCIt definition : An orally available, acyclic retinoid with potential antineoplastic and chemopreventive
activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR),
which in turn recruit coactivator proteins and promote, with other transcriptional
complexes, the transcription of target genes. As a result, this agent may modulate
the expression of genes involved in the regulation of cell proliferation, cell differentiation,
and apoptosis of both normal and tumor cells.;
UNII : 11ALM7A4RV;
InChIKey : UUBHZHZSIKRVIV-KCXSXWJSSA-N;
CAS number : 81485-25-8;
Molecule name : NIK-333;
Chemical formula : C20H30O2;
Origin ID : C87202;
UMLS CUI : C1453741;
Automatic exact mappings (from CISMeF team)
- (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid [MeSH Supplementary Concept]
- Semantic type(s)
- UMLS correspondences (same concept)
- (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid [MeSH concept]
- (2E,4E,6E,10E)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid [MeSH Supplementary Concept]
- concept_is_in_subset
