Chlordiazepoxide Hydrochloride/Clidinium Bromide

Preferred Label : Chlordiazepoxide Hydrochloride/Clidinium Bromide;

NCIt definition : A combination formulation containing the hydrochloride salt form of the benzodiazepine chlordiazepoxide and the bromide salt form of the quaternary ammonium antimuscarinic clidinium with anxiolytic, sedative and antispasmodic activities. Chlordiazepoxide binds to a specific benzodiazepine-binding site on the gamma-aminobutyric acid (GABA)-A receptor in the central nervous system (CNS). This leads to an increase in the opening of chloride channels, membrane hyperpolarization and increases the inhibitory effect of GABA on the CNS. Clidinium binds to and blocks muscarinic receptors in the gastrointestinal (GI) tract. This leads to a decrease in stomach secretions, GI motility and GI spasms.;

Drug name : Librax;

Details

Origin ID

C87060;

UMLS CUI

C1302119;

Automatic exact mappings (from CISMeF team)
- chlordiazepoxide, clidinium drug combination [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Chlordiazepoxide hydrochloride+clidinium bromide (product) [Inactive SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Chlordiazepoxide hydrochloride+clidinium bromide (product) [Inactive SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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