Undifferentiated High Grade Pleomorphic Sarcoma of Bone

Preferred Label : Undifferentiated High Grade Pleomorphic Sarcoma of Bone;

NCIt synonyms : Malignant Fibrous Histiocytoma of the Bone; Malignant Bone Fibrous Histiocytoma; Undifferentiated High Grade Pleomorphic Sarcoma; Malignant Fibrous Histiocytoma of Bone;

NCIt related terms : Undifferentiated high-grade pleomorphic sarcoma; Malignant fibrous histiocytoma (MFH) of bone;

NCIt definition : A rare, high-grade pleomorphic malignant neoplasm arising from the bone. It usually presents with pain which may or may not be associated with swelling in the affected area. It is characterized by the presence of spindle-shaped cells, polygonal or epithelioid cells, multinucleated giant cells, and inflammatory cells. The neoplastic cells exhibit nuclear pleomorphism and high mitotic activity. It metastasizes frequently, most often in the lungs.;

Neoplastic status : Malignant;

Details

Origin ID

C8563;

UMLS CUI

C0740479;

Automatic exact mappings (from CISMeF team)
- Fibrous histiocytoma, malignant (morphologic abnormality) [SNOMED CT concept]
- Malignant fibrous histiocytoma [ICD-11 Extension code]
- malignant fibrous histiocytoma of bone [DO Concept]
DO Cross reference
- malignant fibrous histiocytoma of bone [DO Concept]
Disease excludes normal cell origin
- Bone Marrow Stem Cell [NCIt concept]
- Epithelial Cell [NCIt concept]
Disease may have findings
- Pain [NCIt concept]
- Pathologic Fracture [NCIt concept]
Excludes anatomical site(s)
- Soft Tissue [NCIt concept]
Has associated anatomic sites
- Bone [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
- Musculoskeletal System [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Malignant fibrous histiocytoma of bone [MedDRA Preferred Term]
- malignant fibrous histiocytoma of bone [DO Concept]
concept_is_in_subset
- CTRP Disease Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Intermediate Filaments Present [NCIt concept]
- Intracytoplasmic Eosinophilic Inclusion [NCIt concept]
disease_excludes_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Connective and Soft Tissue Cell [NCIt concept]
- Malignant Spindle-Shaped Fibrohistiocytic Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Multinucleated Giant Cell [NCIt concept]
disease_has_finding
- High Grade Lesion [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Nuclear Pleomorphism [NCIt concept]
- Storiform Growth Pattern [NCIt concept]
disease_has_normal_tissue_origin
- Connective Tissue [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone [NCIt concept]

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