Thioacetazone - CISMeF

Preferred Label : Thioacetazone;

NCIt synonyms : Thiacetazone; N-(4-(ethanethioamidoimino)methylphenyl)acetamide;

NCIt definition : A thiosemicarbazone prodrug with antitubercular activity. Although the exact mechanism by which thioacetazone exerts its effect has yet to be fully elucidated, this agent, upon activation by bacterial monooxygenase EtaA, appears to target and inhibit cyclopropane mycolic acid synthases (CMASs), a family of S-adenosyl-methionine-dependent methyl transferases responsible for cyclopropanation of mycolic acid. By inhibiting mycolic acid synthesis, the bacterial cell wall becomes more permeable and less resistant to injury which eventually leads to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.;

CAS number : 104-06-3;

Details

Origin ID

C85523;

UMLS CUI

C0039834;

Currated CISMeF NLP mapping
- Thiacetazone [LOINC component]
- Thiacetazone (substance) [SNOMED CT concept]
- Thioacetazone [ICD-11 Extension code]
- Thioacetazone [ICHI extension code]
- thioacetazone [ATC Code]
- thioacetazone [Substance BNPC]
- thioacetazone [MeSH Descriptor]
- thioacetazone [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Thiacetazone [LOINC component]
- Thiacetazone (substance) [SNOMED CT concept]
- Thioacetazone [ICD-11 Extension code]
- thioacetazone [ATC Code]
- thioacetazone [Substance BNPC]
- thioacetazone [MeSH concept]
- thioacetazone [MeSH Descriptor]
Validated automatic mappings to BTNT
- thioacetazone [ATC Code]

Keyword's position in hierarchy(ies) :

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