NCIt definition : A proprietary formulation of resveratrol, a polyphenolic phytoalexin derived from
grapes and other food products with potential antioxidant, anti-obesity, antidiabetic
and chemopreventive activities. Resveratrol may activate sirtuin subtype 1 (SIRT-1).
SIRT1 activation has been reported to inhibit tumorigenesis and tumor cell proliferation.
SIRT-1 is a member of the silent information regulator 2 (SIR2) (or sirtuin) family
of enzymes that plays an important role in mitochondrial activity and acts as a protein
deacetylase. SIRT1 appears to be involved in the regulation of numerous transcription
factors such as NF-kB and p53.;