Preferred Label : Buprenorphine Transdermal Matrix Patch;
NCIt synonyms : Transdermal Buprenorphine;
NCIt definition : A transdermal matrix patch containing the synthetic opioid buprenorphine with analgesic
and sedative activities. Buprenorphine binds to and activates the mu-opioid receptors
in the central nervous system (CNS), thereby mimicking the effects of the endogenous
opiates. Binding to opioid receptors stimulates exchange of GTP for GDP, inhibits
adenylate cyclase, and decreases intracellular cAMP. This inhibits the release of
various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid
(GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In
addition, buprenorphine closes N-type voltage-gated calcium channels and opens calcium-dependent
inwardly rectifying potassium channels, resulting in hyperpolarization, reduced neuronal
excitability, analgesia and sedation. Buprenorphine is a partial agonist at the mu-opioid
receptor and an antagonist at the kappa-opioid receptor in the CNS.;
NCI Metathesaurus CUI : CL412371;
Origin ID : C85483;
UMLS CUI : C2827706;
Semantic type(s)
- concept_is_in_subset
