Preferred Label : Ferumoxides Injectable Solution;
NCIt definition : An injectable, aqueous colloid solution containing a non-stoichiometric magnetite
core of superparamagnetic iron oxide (SPIO) coated with dextran administered as a
magnetic resonance imaging (MRI) contrast media. Upon intravenous administration,
ferumoxides accumulates in phagocytic reticuloendothelial system (RES) cells of the
liver (Kupffer cells). When exposed to a strong external magnetic field, ferumoxides
exhibits enhanced T2 relaxation, resulting in signal loss in normal tissues (image
darkening) on mid T1/T2 or strongly T2-weighted images. Tissues with decreased RES
function such as metastases, primary liver cancer, cysts and various benign tumors,
adenomas, and hyperplasia, retain their native signal intensity, consequently the
contrast between normal tissue (with image darkening) and abnormal tissue is increased.;
Drug name : Feridex;
Origin ID : C85477;
UMLS CUI : C1250871;
Semantic type(s)
- concept_is_in_subset
