Preferred Label : Carbon C 14 Eribulin Acetate;
NCIt synonyms : 14C-Eribulin Acetate;
NCIt definition : A radioconjugate containing the acetate salt of eribulin, labeled with the beta particle-emitting
radioisotope carbon C 14, with radioisotopic and potential antineoplastic activities.
Upon administration, eribulin binds to the vinca domain of tubulin and inhibits the
polymerization of tubulin and the assembly of microtubules, resulting in inhibition
of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially,
tumor regression. The radioisotope moiety of this agent acts as a radioactive tracer.;
NCI Metathesaurus CUI : CL412350;
Origin ID : C85472;
UMLS CUI : C2827694;
Semantic type(s)
- concept_is_in_subset
