Eprenetapopt - CISMeF

Preferred Label : Eprenetapopt;

NCIt synonyms : PRIMA-1MET;

NCIt definition : A methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis), with potential antineoplastic activity. Upon administration, eprenetapopt covalently modifies the core domain of mutated forms of cellular tumor antigen p53 (p53) through the alkylation of thiol groups. These modifications restore both the wild-type conformation and function to mutant p53, which reconstitutes endogenous p53 activity, leading to cell cycle arrest and apoptosis in tumor cells. This agent may work synergistically with other antineoplastic agents. p53, a tumor suppressor and transcription factor normally activated upon DNA damage, is frequently mutated and overexpressed in cancer cells; it plays a key role in both DNA repair and the induction of apoptosis.;

UNII : Z41TGB4080;

InChIKey : BGBNULCRKBVAKL-UHFFFAOYSA-N;

CAS number : 5291-32-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 5291-32-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : APR-246;

Details

Origin ID

C85465;

UMLS CUI

C5447987;

Currated CISMeF NLP mapping
- eprenetapopt [MeSH Supplementary Concept]
- eprenetapopt [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- APR-246 [MeSH concept]
- eprenetapopt [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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