Preferred Label : Anti-GnRH Vaccine PEP223;
NCIt definition : A peptide vaccine derived from the synthetic peptide pyroEHWSYGLRPG, corresponding
to amino acids 22-31 of mouse gonadotropin releasing hormone (GnRH), with potential
immunocastration activity. PEP223 is dimerized and contains a D-lysine (k) substitution
at position 6 (pyroEHWSYkLRPG) to increase its immunogenicity. Anti-GnRH vaccine PEP223
may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against
GnRH, neutralizing its activity. In turn, testosterone production and tumor cell growth
may be inhibited in testosterone-sensitive tumors.;
Molecule name : PEP223;
NCI Metathesaurus CUI : CL412337;
Origin ID : C85464;
UMLS CUI : C2827687;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
