Preferred Label : Technetium Tc-99m-NC100692;
NCIt synonyms : Tc-99m-NC100692;
NCIt definition : A synthetic Arg-Gly-Asp (RGD)-containing cyclic peptide radiolabeled with technetium
Tc 99m with integrin-binding and radioisotopic activities. Upon administration, technectium
Tc 99m-NC100692 binds to alpha5beta3 integrin and to a lesser extent alpha5beta5;
subsequently, alpha5beta3-expressing tumor cells can be visualized using scintigraphy
and the degree of tumor angiogenesis can be determined. Integrins, membrane-spanning
protein receptors, may be upregulated on proliferating endothelial cells; their overexpression
has been associated with neovascularization, differentiation, proliferation of tumor
cells and poor prognosis.;
NCI Metathesaurus CUI : CL412329;
Origin ID : C85458;
UMLS CUI : C2827681;
Semantic type(s)
- concept_is_in_subset
