Preferred Label : HLA-A*2402-Restricted URLC10-CDCA1-VEGFR1-VEGFR2 Multipeptide Vaccine;
NCIt definition : A cancer vaccine containing four HLA-A*2402-restricted peptide epitopes with potential
immunostimulatory and antitumor activities. The peptide epitopes are derived from
URLC10 (up-regulated lung cancer 10); CDCA1 (cell division associated 1); and vascular
endothelial growth factor receptors (VEGFRs) 1 and 2. Upon administration, HLA-A*2402-restricted
URLC10-CDCA1-VEGFR1-VEGFR2 multipeptide vaccine may stimulate a cytotoxic T lymphocyte
(CTL) response against URL10-, CDCA1-, VEGFR1- and VEGFR2-expressing tumor cells,
resulting in tumor cell lysis and decreased tumor cell proliferation. HLA-A*2402 is
an MHC class I molecule that presents antigenic peptides to CD8 T cells; epitope
design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve
antigenic peptide immunogenicity.;
NCI Metathesaurus CUI : CL412326;
Origin ID : C85455;
UMLS CUI : C2827678;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
