NCIt definition : A recombinant, soluble glycosylated form of human angiotensin converting enzyme 2
(rhACE2) with antihypertensive and potential antineoplastic activities. Alunacedase
Alfa may normalize ACE2 levels, cleaving angiotensin II to create angiotensin-(1-7)
and restoring the function of the renin-angiotensin system (RAS). ACE2, a homolog
of ACE1, appears to function as a negative regulator of the RAS system by converting
angiotensin II to angiotensin-(1-7), a peptide with actions that counteract the cardiovascular
actions of angiotensin II. In addition, angiotensin-(1-7) may inhibit cyclooxygenase
2 (COX-2) and the production of proinflammatory prostaglandins and may activate the
angiotensin-(1-7) G protein-coupled receptor Mas, resulting in diminished tumor cell
proliferation. ACE2 levels may be reduced in malignancy and diabetes and in liver,
cardiovascular and lung diseases.;
UNII : FA2I4Z873U;
CAS number : 2416824-55-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2416824-55-8
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