Preferred Label : Iodine I 131 Iopofosine;
NCIt synonyms : I-131 PLE Analogue CLR1404; I-131-CLR1404; PDC CLR 131; CLR 1404 I-131; [131I]-CLR1404; NM-404 I-131; Phospholipid Ether-drug Conjugate CLR 131; 131I-NM-404; CLR131; 131I-NM404; 131I-CLR1404; CLR-131; CLR-1404 I-131; Iopofosine I 131; [(131)I]NM404;
NCIt related terms : IOPOFOSINE I-131;
NCIt definition : A radioconjugate composed of iopofosine, a phospholipid ether analog, labeled with
the radioactive isotope iodine I 131, with potential antineoplastic activity. Upon
administration, iodine I 131 iopofosine selectively accumulates in and retains within
tumor cells for a prolonged period of time due to the decreased activity of a phospholipase
D (PLD) in tumor cells compared to normal cells, thereby delivering cytotoxic radiation
specifically to tumor cells. PLD is an enzyme found in the cell membrane of normal
cells that degrades phospholipids.;
UNII : R048696O9L;
CAS number : 873438-88-1;
Molecule name : CLR 131;
Origin ID : C84879;
UMLS CUI : C5670978;
Semantic type(s)
- concept_is_in_subset
