Preferred Label : Melphalan Hydrochloride/Sulfobutyl Ether Beta-Cyclodextrin Complex;
NCIt definition : A propylene glycol-free intravenous formulation containing the hydrochloride salt
of the nitrogen mustard phenylalanine derivative melphalan complexed with polyanionic
sulfobutyl ether beta-cyclodextrin (SBE-CD) with potential antineoplastic activity.
Upon administration, melphalan is converted into highly reactive ethylenimmonium intermediates
that induce covalent guanine N7-N7 intra- and inter-crosslinks and alkylation of adenine
N3 of DNA; RNA and proteins may also be alkylated. Subsequently, RNA transcription
and protein synthesis are inhibited, resulting in cell growth arrest. The addition
of sulfobutyl ether beta-cyclodextrin to the formulation improves the solubility,
stability and ease of use of melphalan; cyclodextrins are cyclic dextrins derived
from starch.;
Drug name : Captisol-enabled Melphalan IV;
NCI Metathesaurus CUI : CL412380;
Origin ID : C84878;
UMLS CUI : C2827551;
Semantic type(s)
- concept_is_in_subset
