Preferred Label : Estradiol/Norethindrone Acetate Tablet;
NCIt definition : An orally bioavailable tablet formulation containing the semisynthetic estrogen estradiol
in combination with the acetate form of the synthetic progestin norethindrone, with
estrogenic and progesteronic activities. Estradiol binds to and activates intracellular
estrogen receptors found in the reproductive tract and other estrogen-responsive tissues.
The activated complex enters the nucleus, binds to the estrogen response elements
on DNA, and activates the transcription of genes involved in the maintenance of the
female reproductive system and secondary sexual characteristics, the proliferation
of the endometrium, and bone metabolism. Norethindrone binds to the intracellular
progesterone receptors in the reproductive system and the activated ligand/receptor
complex interacts with specific DNA response elements, resulting in an alteration
in protein synthesis; inhibition of luteinizing hormone (LH) and follicle stimulating
hormone (FSH) release; inhibition of ovulation; an increase in cervical mucus production;
and induction of the secretory phase of the endometrial cycle. Administration of estradiol/norethindrone
acetate may abrogate vasomotor symptoms associated with menopause and prevent bone
loss associated with the postmenopause. Because chronic estrogen stimulation unopposed
by progesterone may increase the risk of the endometrial carcinoma, administration
of a combination estrogen-progestin in postmenopause may reduce the risk for women
who require estrogen replacement therapy.;
Drug name : Activella;
NCI Metathesaurus CUI : CL938205;
Origin ID : C84875;
UMLS CUI : C2827549;
Semantic type(s)
- concept_is_in_subset
