Preferred Label : Progesterone Vaginal Insert;
NCIt definition : A tablet preparation formulated for vaginal administration containing a micronized
synthetic form of the endogenous steroid hormone progesterone with progesterone activity.
Upon vaginal insertion, progesterone binds to the progesterone receptor, resulting
in dissociation of heat shock proteins, receptor phosphorylation, and transcription
activation through direct or indirect interaction with transcription factors. This
agent exerts inhibitory effects on estrogen by decreasing the number of estrogen receptors
and increasing its metabolism to inactive metabolites. Progesterone induces secretory
changes in the endometrium, decreases uterine contractility during pregnancy, and
maintains pregnancy.;
Drug name : Endometrin;
Origin ID : C84874;
UMLS CUI : C2981233;
Semantic type(s)
- concept_is_in_subset
