Recombinant Human Anti-TGF-beta Monoclonal Antibody

Preferred Label : Recombinant Human Anti-TGF-beta Monoclonal Antibody;

NCIt synonyms : Recombinant Human Anti-Transforming Growth Factor-beta Monoclonal Antibody;

NCIt related terms : GC1008;

NCIt definition : A recombinant human IgG4 monoclonal antibody directed against transforming growth factor-beta (TGFb) with potential antineoplastic activity. Recombinant human anti-TGF-beta monoclonal antibody specifically targets and binds to all 3 isoforms of TGFb, thereby neutralizing TGFb isoforms 1, 2 and 3. This prevents activation of TGFb-mediated signaling pathways. TGFb, a pleiotropic cytokine, is often overexpressed in a number of cancer cell types and is involved in cancer cell proliferation, differentiation, migration, invasion and angiogenesis.;

Alternative definition : NCI-GLOSS: A monoclonal antibody being studied in the treatment of kidney cancer, melanoma, and pulmonary fibrosis. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. GC1008 binds to the protein transforming growth factor-beta (TGF?) and may block the growth of cancer cells that make it.;

Molecule name : GC1008;

Codes from synonyms : CDR0000527378;

Details

Origin ID

C84873;

UMLS CUI

C2987643;

Currated CISMeF NLP mapping
- fresolimumab [MeSH Supplementary Concept]
- fresolimumab [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- fresolimumab [MeSH Supplementary Concept]
- fresolimumab [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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