Preferred Label : Non-Small Cell Lung Cancer mRNA-Derived Vaccine CV9201;
NCIt definition : A non-small cell lung cancer (NSCLC) vaccine containing modified mRNAs encoding cancer-testis
antigen NY-ESO-1, melanoma-associated antigens C1 (MAGE-C1/CT7) and C2 (MAGE-C2/CT10),
survivin, and the oncofetal antigen 5T4 with potential antitumor and immunomodulatory
activities. Upon subcutaneous administration, non-small cell lung cancer mRNA-derived
vaccine CV9201 may stimulate the immune system to mount a cytotoxic, antigen-specific
T lymphocyte response (CTL) against NSCLC cells. The modified mRNAs in this vaccine
are taken up by cells after injection and exhibit enhanced translational potency.
The five tumor-associated antigens (TAAs) encoded by these mRNAs are frequently expressed
by NSCLC cells.;
Molecule name : CV9201;
NCI Metathesaurus CUI : CL412376;
Origin ID : C84872;
UMLS CUI : C2827548;
Semantic type(s)
- concept_is_in_subset
