Preferred Label : Ghrelin Peptide Analogue;
NCIt definition : A ghrelin peptide analogue with potential anti-cachexia activity. Upon subcutaneous
administration, ghrelin peptide analogue binds to and stimulates the G protein-coupled
growth hormone secretagogue receptor (GHSR) in the central nervous system (CNS), thereby
mimicking the appetite-stimulating and growth hormone-releasing effects of endogenous
ghrelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory
cytokines TNF-alpha and interleukin-6, which may play direct roles in cancer-related
loss of appetite. Ghrelin, naturally secreted by gastric endocrine cells, is a 28
amino acid peptide and an endogenous ligand for GHSR.;
NCI Metathesaurus CUI : CL412389;
Origin ID : C84868;
UMLS CUI : C2827545;
Semantic type(s)
- concept_is_in_subset
