Preferred Label : Menadione Topical Lotion;
NCIt definition : A topical lotion containing the small organic molecule protein tyrosine phosphatase
(PTP) inhibitor menadione (vitamin K3) with potential EGFR- and ErbB2/HER2-activating
activities. Upon topical administration, menadione binds to and inhibits the activity
of PTPs that dephosphorylate and inactivate EGFR and ErbB2 in human keratinocytes;
local reversal of EGFR and ErbB2 inhibition associated with the systemic administration
of EGFR inhibitors may help alleviate EGFR inhibitor-mediated skin toxicity. EGFR
(epidermal growth factor receptor) and ErbB2/HER2 (erythroblastic leukemia viral oncogene
homolog 2/ human epidermal growth factor receptor 2) are cell surface receptors that
are upregulated in a number of cancer cells types and play important roles in the
growth and maintenance of normal epithelial tissues.;
NCI Metathesaurus CUI : CL412424;
Origin ID : C84863;
UMLS CUI : C2827540;
Semantic type(s)
- concept_is_in_subset
