Preferred Label : Morphine Sulfate Sustained-Release Tablet;
NCIt definition : A sustained-release tablet formulation containing the sulfate salt of the opiate alkaloid
morphine with analgesic activity. Morphine binds to and activates the mu-opioid receptors
in the central nervous system (CNS), thereby mimicking the effects of the endogenous
opioids. Binding of morphine to opioid receptors stimulates exchange of GTP for GDP,
inhibits adenylate cyclase, and decreases intracellular cAMP. This inhibits the release
of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric
acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin.
In addition, morphine closes N-type voltage-gated calcium channels and opens calcium-dependent
inwardly rectifying potassium channels, which results in hyperpolarization of neuronal
membranes and a reduction in neuronal excitability, and subsequently, analgesia and
sedation.;
NCI Metathesaurus CUI : CL412993;
Origin ID : C84853;
UMLS CUI : C2827530;
Semantic type(s)
- concept_is_in_subset
