Preferred Label : Sufentanil Transdermal System;
NCIt definition : A transdermal matrix patch formulation containing the synthetic opioid sufentanil
with analgesic activity. Sufentanil binds to and activates the mu-opioid receptors
in the central nervous system (CNS), thereby mimicking the effects of the endogenous
opioids. Binding of sufentanil to opioid receptors stimulates exchange of GTP for
GDP, inhibits adenylate cyclase, and decreases intracellular cAMP. This inhibits the
release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric
acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin.
In addition, sufentanil closes N-type voltage-gated calcium channels and opens calcium-dependent
inwardly rectifying potassium channels, which results in hyperpolarization of neuronal
membranes and a reduction in neuronal excitability, and, subsequently, analgesia and
sedation.;
Drug name : Sufentanil TDS;
NCI Metathesaurus CUI : CL412410;
Origin ID : C84852;
UMLS CUI : C2827529;
Semantic type(s)
- concept_is_in_subset
