16,16-Dimethyl Prostaglandin E2

Preferred Label : 16,16-Dimethyl Prostaglandin E2;

NCIt synonyms : dmPGE2; 16,16-Dimethylprostaglandin E2;

NCIt definition : A stable derivative of prostaglandin E2 (PGE2) with potential hematopoietic activity. Administration of 16,16 dimethyl-prostaglandin E2 (dmPGE2) appears to lead to increased formation of hematopoietic stem and progenitor cells. Even though the exact mechanism of action has yet to be fully elucidated, this agent may stimulate hematopoiesis by activating the Wnt signaling pathway, which increases cellular levels of beta-catenin, a subunit of the cadherin protein complex.;

UNII : M790V82VAC;

CAS number : 39746-25-3;

NCI Metathesaurus CUI : CL412404;

Details

Origin ID

C84850;

UMLS CUI

C0000139;

Currated CISMeF NLP mapping
- 16,16-Dimethylprostaglandin E2 [MeSH concept]
- 16,16-Dimethylprostaglandin E2 [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 16,16-Dimethylprostaglandin E2 [MeSH Descriptor]
- 16,16-Dimethylprostaglandin E2 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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