Preferred Label : Oncolytic HSV1716;
NCIt related terms : HUMAN HERPESVIRUS 1, 1716 (ICP 34.5 DELETION);
NCIt definition : A neuroattenuated, replication-restricted, ICP34.5 deleted (RL1 gene)-mutant herpes
simplex virus (HSV) type I, constructed from wild-type strain 17, with potential oncolytic
activity. Upon intratumoral injection, oncolytic HSV1716 transfects, replicates in,
and lyses rapidly dividing cells such as tumor cells. Because the RL1 gene is deleted,
HSV1716 is unable to replicate in non-dividing cells.;
UNII : 26WEP2905N;
Molecule name : HSV1716;
NCI Metathesaurus CUI : CL412391;
Origin ID : C84840;
UMLS CUI : C2827518;
Semantic type(s)
- concept_is_in_subset
