Fulranumab - CISMeF

Preferred Label : Fulranumab;

NCIt synonyms : Anti-NGF Monoclonal Antibody JNJ-42160443;

NCIt definition : A fully human monoclonal antibody directed against nerve growth factor (NGF) with potential analgesic activity. Upon administration, fulranumab binds to NGF, preventing its binding to and activation of the NGF receptors TrkA and p75NTR. Inhibition of the NGF pathway may prevent the perception of pain and may induce analgesia. NGF, a neurotrophic factor that plays a key role in neuropathic and inflammatory-induced pain, promotes hyperalgesia and allodynia.;

UNII : 0E986JU40I;

CAS number : 902141-80-4;

Molecule name : JNJ-42160443; AMG 403;

Details

Origin ID

C84838;

UMLS CUI

C2981231;

Currated CISMeF NLP mapping
- fulranumab [MeSH concept]
- fulranumab [MeSH Supplementary Concept]
False automatic mappings
- AMG 403 [MeSH Supplementary Concept]
- AMG 403 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- fulranumab [MeSH concept]
- fulranumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Beta-Nerve Growth Factor [NCIt concept]

Keyword's position in hierarchy(ies) :

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