Preferred Label : hTERT/Survivin/Melanoma Tumor Cell-Derived mRNA-Transfected Dendritic Cell Vaccine;
NCIt definition : A cancer vaccine containing dendritic cells (DCs) that are transfected with messenger
RNA (mRNA) encoding human telomerase reverse transcriptase (hTERT) and survivin in
addition to patient-specific melanoma-derived mRNA with potential immunostimulatory
and antineoplastic activities. Upon administration, hTERT/survivin/melanoma tumor
cell-derived mRNA-transfected dendritic cell vaccine may elicit a highly specific
cytotoxic T-cell (CTL) response against melanoma cells expressing hTERT, survivin,
and patient-specific melanoma-associated antigens. hTERT, the catalytic subunit of
human telomerase, and survivin, a member of the inhibitor of apoptosis (IAP) family
of proteins, may be upregulated in certain tumor cell types, playing key roles in
tumor cell growth and survival.;
NCI Metathesaurus CUI : CL412432;
Origin ID : C84755;
UMLS CUI : C2827502;
Semantic type(s)
- concept_is_in_subset
