NCIt synonyms : Immunoglobulin, Anti-(Human Glycoprotein NMB Extracellular Domain) (Human Monoclonal
CR011 Heavy Chain), Disulfide with Human Monoclonal CR011 Gamma-2 Kappa-Chain, Dimer; Immunoglobulin G2, Anti-(Human Transmembrane Glycoprotein NMB (HGFIN) Extracellular
Domain) Human Monoclonal CR011 Heavy Chain (133-215')-Disulfide with Human Monoclonal
CR011 Kappa Light Chain, Dimer (221-221'':222-222'':225-225'':228- 228'')-Tetrakis;
NCIt definition : A human monoclonal antibody against transmembrane glycoprotein non-metastatic melanoma
protein B (GPNMB). Glembatumumab binds to GPNMB on cancer cells, but alone does not
appear to inhibit cancer cell growth. However, this antibody could be utilized to
deliver a conjugated cytotoxic agent to GPNMB-expressing tumor cells. GPNMB, overexpressed
on the surface of various cancer cells, plays a key role in cancer cell proliferation.;
UNII : WEC7MEM1BR;
CAS number : 1020264-78-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1020264-78-1
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