Preferred Label : Tafamidis Meglumine;
NCIt synonyms : D-Gluco-2,3,4,5,6-Pentahydroxy-N-Methylhexan-1-Aminium 2-(3,5-Dichlorophenyl)Benzoxazole-6-Carboxylate; D-Glucitol, 1-Deoxy-1-(Methylamino)-, 2-(3,5-Dichlorophenyl)-6-Benzoxazolecarboxylate
(1:1);
NCIt definition : A soft gelatin capsule formulation containing the meglumine salt form of tafamidis,
a small molecule and pharmacological chaperone with potential disease-modifying activity.
Tafamidis binds to and stabilizes wild-type and variant (V122I) transthyretin (TTR),
thereby preventing tetramer dissociation into monomers; this prevents misfolding of
the TTR protein and inhibits the formation of TTR amyloid fibrils and the subsequent
deposition of these insoluble protein clusters in peripheral nerve tissues and organs.
TTR is a 127 amino acid transport protein for thyroxine and retinol and is secreted
by the liver.;
UNII : ZU7CF08A1A;
InChIKey : DQJDBUPLRMRBAB-WZTVWXICSA-N;
CAS number : 951395-08-7;
Molecule name : FX-1006A;
Chemical formula : C14H7Cl2NO3.C7H17NO5;
Origin ID : C84194;
UMLS CUI : C2745275;
CISMeF manual mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
