NCIt definition : The hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast
and disinfectant agent that can potentially be used for cellular imaging and antiseptic
purposes. Upon topical application of proflavine hemisulfate, proflavine diffuses
into cells and intercalates into DNA, thereby accumulating in and staining the nucleus.
During fluorescence imaging, the cell nuclei can be visualized. This allows nuclear
morphometry and the identification of cancer cells. In addition, proflavine exerts
its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis
and halting bacterial cell growth.;