Preferred Label : Nicorandil;
NCIt synonyms : 2-Nicotinamidoethyl Nitrate; 3-Pyridinecarboxamide, N-(2-(nitroxy)ethyl)-;
NCIt definition : A niacinamide derivative, a plasma membrane adenosine triphosphate (ATP)-sensitive
potassium (K ) (KATP) channel activator and a nitric oxide (NO) donor, with vasodilatory,
antihypertensive and potential cardio- and lung-protective activities. Upon administration,
nicorandil binds to and opens KATP channels, which causes relaxation of vascular smooth
muscles, stimulates vasodilatation, reduces vasoresistance, decreases blood pressure
and protects the myocardium against ischemia. In addition, nicorandil exerts nitrate-like
properties, through the stimulation of guanylate cyclase, the downregulation of Rho-kinase
activity and the further promotion of venous vasodilation. Although the mechanism
of action has not been fully elucidated, nicorandil may exhibit protective activity
against radiation-induced lung and heart toxicity, possibly by preventing both accumulation
of reactive oxygen species (ROS) and ROS-induced cellular damage.;
UNII : 260456HAM0;
InChIKey : LBHIOVVIQHSOQN-UHFFFAOYSA-N;
CAS number : 65141-46-0;
Drug name : Sigmart; Angedil; Nitorubin; Ikorel; Aprior; Nikoran; Dancor;
Chemical formula : C8H9N3O4;
Origin ID : C84012;
UMLS CUI : C0068700;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
